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An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis
Lees, N. R., Han, L-C., Byrne, M., Davies, J., Parnell, A., Moreland, P., Stach, J. E. M., Van der Kamp, M., Willis, C. & Race, P., 18 Feb 2019, In: Angewandte Chemie - International Edition. 58, 8, p. 2305-2309 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile6 Citations (Scopus)166 Downloads (Pure) -
Catalytic mechanism of the colistin resistance protein MCR-1
Suardíaz, R., Lythell, E., Hinchliffe, P., van der Kamp, M., Spencer, J., Fey, N. & Mulholland, A. J., 7 May 2021, In: Organic and Biomolecular Chemistry. 19, 17, p. 3813-3819 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile4 Citations (Scopus)81 Downloads (Pure) -
Adaptation and implementation of the ARK (Antibiotic Review Kit) intervention to safely and substantially reduce antibiotic use in hospitals: a feasibility study
Cross, E. L. A., Sivyer, K., Islam, J., Santillo, M., Mowbray, F., Peto, T. E. A., Walker, A. S., Yardley, L. & Llewelyn, M. J., 1 Nov 2019, In: Journal of Hospital Infection. 103, 3, p. 268-275 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile5 Citations (Scopus)50 Downloads (Pure) -
Do NHS GP surgeries employing GPs additionally trained in Integrative or Complementary Medicine have lower antibiotic prescribing rates? Retrospective cross-sectional analysis of national primary care prescribing data in England in 2016
van der Werf-Kok, E., Duncan, L., von Flotow, P. & Baars, E. W., 19 Mar 2018, In: BMJ Open. 8, 3, 9 p., e020488.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile11 Citations (Scopus)248 Downloads (Pure) -
Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants
Lohans, C. T., Chan, H. T. H., Malla, T. R., Kumar, K., Kamps, J. J. A. G., McArdle, D. J. B., van Groesen, E., de Munnik, M., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. & Schofield, C. J., 11 Feb 2019, In: Angewandte Chemie - International Edition. 58, 7, p. 1990-1994 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile14 Citations (Scopus)229 Downloads (Pure) -
Responsive materials based on magnetic polyelectrolytes and graphene oxide for water clean-up
Hazell, G. D. A., Hinojosa Navarro, M. A., Tabor, R. F., McCoy, T. M. & Eastoe, J., 15 Feb 2016, In: Journal of Colloid and Interface Science. 464, p. 285-290 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile18 Citations (Scopus)317 Downloads (Pure) -
A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation
Lohans, C. T., van Groesen, E., Kumar, K., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. & Schofield, C. J., Jan 2018, In: Angewandte Chemie - International Edition. 57, 5, p. 1282-1285 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile17 Citations (Scopus)215 Downloads (Pure) -
Exploring the appropriateness of antibiotic prescribing for common respiratory tract infections in UK primary care
Stuart, B., Brotherwood, H., Van't Hoff, C., Brown, A., Van den Bruel, A., Hay, A. D., Moore, M. V. & Little, P., 1 Jan 2020, In: Journal of Antimicrobial Chemotherapy. 75, 1, p. 236–242 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile7 Citations (Scopus)53 Downloads (Pure) -
Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants
Damiati, L., Eales, M. G., Nobbs, A. H., Su, B., Tsimbouri, P. M., Salmeron-Sanchez, M. & Dalby, M. J., 18 Aug 2018, In: Journal of Tissue Engineering. 9, p. 2041731418790694Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile78 Citations (Scopus)266 Downloads (Pure) -
New NICE abortion care guidance: what does it mean for antibiotic use?
Blee, K. & Horner, P. J., 16 Apr 2020, (E-pub ahead of print) In: BMJ sexual & reproductive health. 1 p.Research output: Contribution to journal › Letter (Academic Journal) › peer-review
Open AccessFile77 Downloads (Pure) -
Symptom reporting, healthcare-seeking behaviour and antibiotic use for common infections: protocol for Bug Watch, a prospective community cohort study
Smith, C. M., Conolly, A., Fuller, C., Hill, S., Lorencatto, F., Marcheselli, F., Michie, S., Mindell, J. S., Ridd, M. J., Shallcross, L. J., Tsakos, G., Hayward, A. & Fragaszy, E. B., 22 May 2019, In: BMJ Open. 9, 5, 6 p., e028676.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile5 Citations (Scopus)122 Downloads (Pure) -
Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
Alberti, F., Khairudin, K., Rodriguez Venegas, E., Davies, J., Hayes, P., Willis, C., Bailey, A. M. & Foster, G., 28 Nov 2017, In: Nature Communications. 8, 1, 1831.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile33 Citations (Scopus)264 Downloads (Pure) -
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
Brem, J., Cain, R., Cahill, S., McDonough, M. A., Clifton, I. J., Jiménez-Castellanos, J-C., Avison, M. B., Spencer, J., Fishwick, C. W. G. & Schofield, C. J., 8 Aug 2016, In: Nature Communications. 7, 8 p., 12406.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile157 Citations (Scopus)357 Downloads (Pure) -
C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae
Wu, J., Zhang, H-B., Xu, J-L., Cox, R. J., Simpson, T. J. & Zhang, L-H., 2010, In: Chemical Communications. 46, 2, p. 333-335 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
32 Citations (Scopus) -
Cross-sectional study of the use of antimicrobials following common infections by rural residents in Anhui, China
Chai, J., Coope, C., Cheng, J., Oliver, I., Kessel, A., Hu, Z. & Wang, D., 11 Apr 2019, In: BMJ Open. 9, 4, p. e024856 e024856.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile8 Citations (Scopus)194 Downloads (Pure) -
Towards the Identification of Antibiotic-Resistant Bacteria Causing Urinary Tract Infections Using Volatile Organic Compounds Analysis-A Pilot Study
Hewett, K., Drabińska, N., White, P., Avison, M. B., Persad, R., Ratcliffe, N. & Costello, B. D. L., 11 Nov 2020, In: Antibiotics. 9, 11Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus) -
1.12 Å resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2
Hinchliffe, P. & Spencer, J., 26 Jul 2017, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile18 Citations (Scopus)371 Downloads (Pure) -
Cost-effectiveness of internet-based training for primary care clinicians on antibiotic prescribing for acute respiratory tract infections in Europe
Oppong, R., Smith, R. D., Little, P., Verheij, T., Butler, C. C., Goossens, H., Coenen, S., Jowett, S., Roberts, T., Achana, F., Stuart, B. & Coast, J., Nov 2018, In: Journal of Antimicrobial Chemotherapy. 73, 11, p. 3189-3198 10 p., dky309.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile9 Citations (Scopus)116 Downloads (Pure) -
Incorporation of Farnesol Significantly Increases the Efficacy of Liposomal Ciprofloxacin against Pseudomonas aeruginosa Biofilms in Vitro
Bandara, H. M. H. N., Herpin, M. J., Kolacny, D., Harb, A., Romanovicz, D. & Smyth, H. D. C., 1 Aug 2016, In: Molecular Pharmaceutics. 13, 8, p. 2760-70 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile34 Citations (Scopus)226 Downloads (Pure) -
The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid
Aggarwal, VK., Roseblade, S. & Alexander, R., 21 Feb 2003, In: Organic and Biomolecular Chemistry. 1, 4, p. 684-691 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
53 Citations (Scopus) -
Enantioselective reduction of β-keto acids with engineered streptomyces coelicolor
Booker-Milburn, K. I., Gillan, R., Kimberley, M., Taguchi, T., Ichinose, K., Richard Stephenson, G., Ebizuka, Y. & Hopwood, D. A., 4 Feb 2005, In: Angewandte Chemie - International Edition. 44, 7, p. 1121-1125 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
9 Citations (Scopus) -
Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC
Cuskin, F., Solovyova, AS., Lewis, RJ. & Race, PR., Apr 2011, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67, 4, p. 464 - 466 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
5 Citations (Scopus) -
A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis
Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, (E-pub ahead of print) In: ACS Chemical Biology. 2020, 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile69 Downloads (Pure) -
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition
Brem, J., van Berkel, S. S., Aik, W., Rydzik, A. M., Avison, M. B., Pettinati, I., Umland, K-D., Kawamura, A., Spencer, J., Claridge, T. D. W., McDonough, M. A. & Schofield, C. J., Dec 2014, In: Nature Chemistry. 6, 12, p. 1084-90 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
88 Citations (Scopus) -
Fast identification and quantification of uropatho-genic E. coli through cluster analysis
Vendeville, J-B., Kyriakides, M. J., Takebayashi, Y., Dorh, J. N., Spencer, J. & Galan, M. C., 13 Dec 2021, (E-pub ahead of print) In: ACS Biomaterials Science and Engineering. 8, 1, 242–252.Research output: Contribution to journal › Article (Academic Journal) › peer-review