Biosynthetic Studies on Kalimantacin Antibiotics

  • Angus N M Weir

Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

Abstract

Kalimantacin A is a polyketide natural product isolated from Pseudomonas fluorescens which exhibits a narrow spectrum of antibiotic activity against Staphylococci, including multidrug resistant strains. It has a fascinating structure which includes three consecutive, but different, β-branches (at C-3, C-5 and C-7). The work described in this thesis is focussed on elucidating how this structural complexity is introduced during kalimantacin biosynthesis and how modifications to the structure affect antibiotic activity.
Date of Award25 Jan 2022
Original languageEnglish
Awarding Institution
  • University of Bristol
SupervisorChris L Willis (Supervisor) & Matthew P Crump (Supervisor)

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