Characterisation of the atypical calpain family of C elegans

  • Peter Joyce

Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)


Regulated proteolysis plays an important role in modulating the activities of receptors, cytoskeletal proteins and transcription factors during cell growth and development. A family of calcium-regulated thiol proteases, known as calpains, has been shown to promote this process in mammals, and other eukaryotes. The importance of calpains is highlighted through their involvement in a number of pathologies in humans.
Date of Award2008
Original languageEnglish

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