Design, Synthesis and Characterisation of Novel Linker Chains under Conformational Control for PROTAC Drug Discovery

Abstract

This thesis is a synergic work of computational modeling, organic synthesis and NMR spectroscopy for the conformational study of small-molecule, PROTAC linker and peptidomimetic foldamer, with applications for rational structure-based drug design.

Date of Award	3 Oct 2023
Original language	English
Awarding Institution	University of Bristol
Supervisor	Craig P Butts (Supervisor) & Varinder K Aggarwal (Supervisor)