Peripheral NMDA receptors in inflammatory and visceral pain

Abstract

Substantial evidence has accumulated for the involvement of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral/chronic pain. Notably, poorly brain-penetrating glycinceB NMDA antagonists were particularly potent in in vivo models of inflammatory visceral pain. The aim of this thesis was to further investigate the pharmacology of peripheral, compared to central, NMDA receptors.

Date of Award	2007
Original language	English