Structural studies on polyketide enzymes

  • Patrick Dall'Aglio

Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)


Polyketides are a class of secondary metabolites that includes compounds with antibiotic and anticancer properties. In type I polyketide synthesis, the individual activities are arranged into large | polyproteins, while in type II polyketide synthesis enzymes are encoded separately. Streptomyces coelicolor actinorhodin acyl carrier protein synthase (AcpS) IS a promiscuous enzyme involved in type II polyketide synthesis that catalyses the transfer of the phosphopantetheine chain from coenzyme A (CoA) to acyl carrier protein (ACP).
Date of Award2008
Original languageEnglish

Cite this