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A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1839-1855
Number of pages17
JournalChild Development
Volume89
Issue number5
Early online date20 Sep 2017
DOIs
DateAccepted/In press - 7 Jun 2017
DateE-pub ahead of print - 20 Sep 2017
DatePublished (current) - Sep 2018

Abstract

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).

    Research areas

  • ALSPAC, Oppositional Defiant Disorder, Irritability, Headstrong, Attention Deficit Hyperactivity Disorder, DNA methylation

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Wiley at http://onlinelibrary.wiley.com/doi/10.1111/cdev.12957/abstract . Please refer to any applicable terms of use of the publisher.

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