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Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

Research output: Contribution to journalArticle

  • XiaoFeng Ma
  • Ian Hazelden
  • Thomas Langer
  • Rachel Munday
  • John Bower
Original languageEnglish
Pages (from-to)3356-3360
Number of pages5
JournalJournal of the American Chemical Society
Issue number8
Early online date9 Feb 2019
DateAccepted/In press - 1 Feb 2019
DateE-pub ahead of print - 9 Feb 2019
DatePublished (current) - 18 Feb 2019


Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and represents
the broadest scope enantioselective aza-Heck protocol developed so far.



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