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Gene-Mediated Chemical Communication in Synthetic Protocell Communities

Research output: Contribution to journalLetter

Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalACS Synthetic Biology
Volume7
Issue number2
Early online date1 Nov 2017
DOIs
DateAccepted/In press - 24 Aug 2017
DateE-pub ahead of print - 1 Nov 2017
DatePublished (current) - 16 Feb 2018

Abstract

A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.

    Research areas

  • cell-free expression, communication, enzyme cascade, genetic switches, lipid vesicles, proteinosomes, α-hemolysin

    Structured keywords

  • BrisSynBio
  • Bristol BioDesign Institute

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via ACS at https://pubs.acs.org/doi/full/10.1021/acssynbio.7b00306 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 613 KB, PDF-document

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