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Near-Wall Flow in Cerebral Aneurysms

Research output: Contribution to journalArticle

Original languageEnglish
Article number89
Number of pages27
JournalFluids
Volume4
Issue number2
Early online date16 May 2019
DOIs
DateAccepted/In press - 18 Apr 2019
DateE-pub ahead of print - 16 May 2019
DatePublished (current) - Jun 2019

Abstract

The region where the vascular lumen meets the surrounding endothelium cell layer, hence the interface region between haemodynamics and cell tissue, is of primary importance in the physiological functions of the cardiovascular system. The functions include mass transport to/from the blood and tissue, and signalling via mechanotransduction, which are primary functions of the cardiovascular system and abnormalities in these functions are known to affect disease formation and vascular remodelling. This region is denoted by the \textit{near-wall} region in the present work, and we outline simple yet effective numerical recipes to analyse the near-wall flow field. Computational haemodynamics solutions are presented for six patient specific cerebral aneurysms, at three instances in the cardiac cycle: peak systole, end systole (taken as dicrotic notch) and end diastole. A sensitivity study, based on Newtonian and non-Newtonian rheological models, and different flow rate profiles, is effected for a selection of aneurysm cases. The near-wall flow field is described by the wall shear stress (WSS) and the divergence of wall shear stress (WSSdiv), as descriptors of tangential and normal velocity components, respectively, as well as the wall shear stress critical points. Relations between near-wall and free-stream flow fields are discussed.

    Structured keywords

  • Mathematics and Computational Biology

    Research areas

  • cerebral aneurysm, computational haemodynamics, no-slip critical points, near-wall transport, description of flow field

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via MDPI at https://www.mdpi.com/2311-5521/4/2/89 . Please refer to any applicable terms of use of the publisher.

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