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Prenatal alcohol exposure and offspring mental health: A systematic review

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)344-353
Number of pages10
JournalDrug and Alcohol Dependence
Early online date28 Feb 2019
DateAccepted/In press - 8 Jan 2019
DateE-pub ahead of print - 28 Feb 2019
DatePublished (current) - 1 Apr 2019


Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear on the association of alcohol use in pregnancy and offspring mental health, specifically for low levels of prenatal alcohol exposure. We conducted a systematic review to evaluate studies examining this association. Methods: Studies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and offspring mental health at age 3 or older as an outcome. We excluded non-English language publications and studies of fetal alcohol syndrome. Results: Thirty-three studies were included and were categorized by mental health outcomes: anxiety/depression, emotional problems, total internalizing problems, total problem score, and conduct disorder. Over half of the analyses reported a positive association of prenatal alcohol exposure and offspring mental health problems. Conclusions: Our review suggests that maternal alcohol use during pregnancy is associated with offspring mental health problems, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference is needed to further investigate if these associations shown are causal.

    Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

    Research areas

  • Alcohol, mental health, pregnancy, prenatal, intrauterine, Systematic review

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    Licence: CC BY


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