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Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Research output: Contribution to journalReview article

  • Angela B. Seddon
  • Bruce Napier
  • Ian Lindsay
  • Samir Lamrini
  • Peter M. Moselund
  • Nicholas Stone
  • Ole Bang
  • Mark Farries
Original languageEnglish
Pages (from-to)5874-5887
Number of pages14
JournalAnalyst
Volume143
Issue number24
Early online date5 Nov 2018
DOIs
DateAccepted/In press - 30 Oct 2018
DateE-pub ahead of print - 5 Nov 2018
DatePublished (current) - 21 Dec 2018

Abstract

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral ‘fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a ‘few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre-an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the ‘fingerprint region'.

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