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Self-Assembled Magnetic Viruslike Particles for Encapsulation and Delivery of Deoxyribonucleic Acid

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)7171-7179
Number of pages9
JournalLangmuir
Volume34
Issue number24
Early online date29 May 2018
DOIs
DateAccepted/In press - 29 May 2018
DateE-pub ahead of print - 29 May 2018
DatePublished (current) - 19 Jun 2018

Abstract

Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (C16H33)2(CH3)2N+[FeCl3Br], which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {Mo72Fe30}/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields. By using cationic Mag-Surfs, the anionic POMs and DNA can be complexed in these ternary mixtures. These virus-shaped complexes act as nanoanchors and nanomotors, which can be utilized for binding, anchoring, and delivery of biomolecules, such as DNA. It is found that they have a good absorption capacity for DNA and myoglobin over 24 h, after application of a magnetic field. The realization of magnetic virus-shaped {Mo72Fe30}/Mag-Surf spheres may open possibilities for designing other functional nanoparticles, allowing effective control over the delivery/separation of biomolecules.

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    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via ACS at https://doi.org/10.1021/acs.langmuir.8b01445 . Please refer to any applicable terms of use of the publisher.

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