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Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Research output: Contribution to journalArticle

Original languageEnglish
Article numbereaaw2853
Number of pages9
JournalScience Advances
Volume5
Issue number9
DOIs
DateAccepted/In press - 21 Aug 2019
DatePublished (current) - 25 Sep 2019

Abstract

Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo–electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.

    Structured keywords

  • Bristol BioDesign Institute
  • BrisSynBio

    Research areas

  • SYNTHETIC BIOLOGY, minimal biology, Biodesign, Vaccine, advanced computing

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via AAAS at https://advances.sciencemag.org/content/5/9/eaaw2853 . Please refer to any applicable terms of use of the publisher.

    Final published version, 757 KB, PDF document

    Licence: CC BY

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