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The JAK/STAT pathway is involved in synaptic plasticity

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)374 - 390
Number of pages16
JournalNeuron
Volume73
Issue number2
DOIs
DatePublished - 26 Jan 2012

Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

Additional information

Publisher: Elsevier Other: Accepted November 2011

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