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Treatments for bulimia nervosa: a network meta-analysis

Research output: Contribution to journalArticle

  • Eric Slade
  • Edna Keeney
  • Ifigeneia Mavranezouli
  • Sofia Dias
  • Linyun Fou
  • Sarah Stockton
  • Leanne Saxon
  • Glenn Waller
  • Hannah Turner
  • Lucy Serpell
  • Christopher G. Fairburn
  • Tim Kendall
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalPsychological Medicine
Early online date6 May 2018
DOIs
DateAccepted/In press - 3 Apr 2018
DateE-pub ahead of print (current) - 6 May 2018

Abstract

Background: Bulimia nervosa (BN) is a severe eating disorder that can be managed using a variety of treatments including pharmacological, psychological, and combination treatments. We aimed to compare their effectiveness and to identify the most effective for the treatment of BN in adults. Methods: A search was conducted in Embase, Medline, PsycINFO, and Central from their inception to July 2016. Studies were included if they reported on treatments for adults who fulfilled diagnostic criteria for BN. Only randomised controlled trials (RCTs) that examined available psychological, pharmacological, or combination therapies licensed in the UK were included. We conducted a network meta-analysis (NMA) of RCTs. The outcome analysed was full remission at the end of treatment. Results: We identified 21 eligible trials with 1828 participants involving 12 treatments, including wait list. The results of the NMA suggested that individual cognitive behavioural therapy (CBT) (specific to eating disorders) was most effective in achieving remission at the end of treatment compared with wait list (OR 3.89, 95% CrI 1.19–14.02), followed by guided cognitive behavioural self-help (OR 3.81, 95% CrI 1.51–10.90). Inconsistency checks did not identify any significant inconsistency between the direct and indirect evidence. Conclusions: The analysis suggested that the treatments that are most likely to achieve full remission are individual CBT (specific to eating disorders) and guided cognitive behavioural self-help, although no firm conclusions could be drawn due to the limited evidence base. There is a need for further research on the maintenance of treatment effects and the mediators of treatment outcome.

    Research areas

  • Bulimia nervosa, eating disorder, National Institute of Health and Care Excellence, network meta-analysis, outcome research

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Cambridge Core at https://www.cambridge.org/core/journals/psychological-medicine/article/treatments-for-bulimia-nervosa-a-network-metaanalysis/E2F5EDDEF98F480DED2FB09AF87C12F8. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 1 MB, PDF document

  • Supporting info PDF

    Accepted author manuscript, 1 MB, PDF document

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